Probiotic New Patent Awarded to Zhongke Jiayi - Bifidobacterium bifidum JYBB-163 for Improving Male Semen Quality and Fertility

         Fertility has always been an important research issue in the field of life sciences. In recent years, the incidence of male and female

 infertility has been increasing, with male infertility accounting for about 40% to 50%. The main causes of male infertility include abnormal

 levels of reproductive endocrine hormones, abnormalities in the development of seminal plasmodesmata testes and epididymis, autoimmunity, 

spermatogenesis, and infections, etc., and are mainly manifested in semen quality abnormalities such as oligozoospermia, weak spermatozoa, 

and spermatozoa malformations. Symptoms. Research has found that testosterone level is one of the factors affecting semen quality, testosterone

 is the basic hormone supporting the growth and development of the male reproductive system, low level testosterone is not conducive to the 

growth of the epididymis and other accessory sex glands, thus affecting the maturation of spermatozoa; and testosterone level directly affects 

spermatozoa development, low level testosterone induces spermatogonial apoptosis, which reduces the number of spermatozoa, and directly 

damages spermatozoa DNA; and at the same time low level testosterone At the same time, low level of testosterone will reduce male libido and

 cause erectile dysfunction, which will reduce the degree of satisfaction of the patient's sex life and indirectly affect the patient's semen quality.

   Currently, methods to improve semen quality and fertility include diet and exercise, and medication. Controlling diet and strengthening exercise 

are very low cost, but difficult to adhere to. Medication is quick, but the effect is not long-lasting and has more side effects. Studies have found that 

regulating changes in gut flora can indirectly contribute to the resolution of reproductive disorders. However, the current technology of intestinal 

flora transplantation is still immature, the therapeutic effect is not stable, and there is no report of probiotic treatment with good repeatability.

The present invention isolates a strain of Bifidobacterium bifidum JYBB-163, and makes it into bacterial agent, and it is verified that JYBB-163 

bacterial agent can obviously enhance the testosterone level and testicular coefficient of mice with high-temperature-treated testes, increase 

the total number of sperms and the mobility rate of sperms, and reduce the sperm malformation rate of sperms; and at the same time JYBB -163 

bacteriophage could significantly enhance the testosterone level and testicular coefficient, and improve the plasma membrane integrity, the proportion

 of normal mitochondrial function and DNA integrity in aging rats. Therefore, Bifidobacterium bifidum JYBB-163 bacterial preparation can help to improve

 semen quality and fertility function in men, and can be used to assist in the treatment of male infertility.

Up to now, Zhongke Jiayi has obtained 21 invention patented probiotic, 2 international invention patents, 13 utility model patents, and 5 soft writings.

In the future, we will continue to pay attention to the protection of intellectual property rights, and will also continue to increase investment in R&D to 

enrich the intellectual property reserves.